Serotonin Mood Support

Brighten your mood and fight back negative thoughts. A patented form of saffron along with other nutrients help promote calmness and a positive mood.


Serotonin Mood Support

Serotonin Mood Support

Dr. Amen’s Serotonin Mood Support contains ingredients shown to support healthy serotonin balance in the brain, lift your mood and promote feelings of calmness.

What is serotonin?
Our brains produce this naturally soothing neurotransmitter called serotonin, from before birth and all through life. Serotonin plays many important roles in the brain’s biochemistry and is intimately involved in facilitating sustained and deep sleep, maintaining healthy mood and self-confidence, even supporting healthy appetite and social engagement.

Serotonin helps control appetite.
Serotonin Mood Support can also help you control your appetite. Feeling blue is often accompanied by increased appetite, which can lead to overeating. Balancing your serotonin levels may help minimize emotional overeating.

Other things you can do to help your mood.
The great news is that lifestyle habits such as daily exercise, consuming “smart” carbohydrates in moderation, and taking a dietary supplement like Serotonin Mood Support can work together to create a positive mood state, which is the foundation of a happier and more satisfying life!




Anxiety Relief

I’ve struggled with feelings of anxiety and panic for almost 10 years. I never wanted to get on prescription medication and preferred to work more on my thoughts, but then I tried a sample just to see. This product has helped calm most of the anxiety and my panic has been nonexistent. I’ve been using it for 9 months now and I’m amazed how much calmer I am overall on a daily basis.

Great mood support, feel calmer!

Serotonin Mood Support works great. I found that after about 1-2 weeks my irritability was less and I felt more calm. I almost didn’t realize how irritable I was until I felt better. I think it also helped decrease my stress food cravings. I will definitely order again!


This product calms me down and makes me a bit more serene during the day. I take it on a regular basis. Would not be without it.

I keep This in my arsenal for sleepless nights.

I have Idiopathic Insomnia. Not all sleep aids work for me. And not all of them that do work are effective each time. So the Serotonin Mood Support is one of my "go to" supplements that helps me get the rest I need. It works best for me if I rotate with the GABA.

Good mood suport, but not sleep

This has helped me calm down and be a bit more focused and energetic to get things done which has been great, but has not done anything for my sleep. Still trouble getting to sleep and keeping asleep when I do get there.

It helps

I went through some traumatic events years ago. Most of the time I am at peace, but I will have days when I get stuck on negative thoughts and ruminate on those events. I decided to try Serotonin Mood Support hoping it would help, and it has. I am able to “kill the ants” much more quickly.

Helped with Occasional Anxiety

This has helped my husband with his occasional anxiety and helped him be more calm

Definitely ordering more!

I’ve only been taking this product for a month but I must admit, if it weren’t for this product, it would have been impossible to avoid medication. Also, I’ve had major life changes in the last month, moving, surgery, financial problems... and I firmly believe this product helped me cope with all of that in a productive way. I’m ordering more and giving it a full two months!

Helping a lot!

After my mom died, I decided to try this product. I take 2 pills twice a day but don't always take the morning dosage. After a few weeks, I noticed a tremendous difference in my mood. While my mood is better, my energy still isn't great so I am considering using with Energy supplement and will give an update then. Definitely worth a try.

Wouldn't want to live without it.

Mood lift, and sleep help, also a help with hunger.

Less anxious after a week's useage.

I used the sample pack for a week, and I seem to be a bit less anxious. I hope that regular use over an extended time will be of great benefit.

IT WORKS!!!!!!

This product worked for me in two ways. I have a hard time sleeping and have tried everything. I take it with water and a tiny snack before bedtime. It really does help me feel drowsy and fall asleep. It also helps me feel calm on a stressful day.

Sticking with this one!

My son started this product a year ago after being seen at the Amen Clinics. Since that time we’ve dropped and added many supplements but this one is here to stay! It helps him calm down and address life and challenges in a pleasant fashion which was very difficult for him to do before.

I'm a forever fan of Serotonin Mood Support!

I had been taking St John's Wart for years to pick my mood up, but every time I would fill a prescription, the pharmacists would advise on how many drugs had negative interactions with St John's Wart. Then, I started getting chronic headaches that would not go away and were apparently being causes the St John's Wart. I went on a search, tried several options, to find an alternative that worked as well without the side effects and drug interactions. I found Serotonin Mood Support. Since taking this product I have had no headaches and it picks my mood up better than the other products. I'm a forever fan of Serotonin Mood Support!

great product

I love this product - it helps my occasional anxiety


I have struggled with my mood, worries, and sleep for the past 20 years. 8 years ago, I started my journey on finding joy and surrounding myself with safe people. Then 11 months ago I started taking Serotonin Mood Support. It has made a real difference and I’m overjoyed to experience a clear view of life.

Been on this supplement and it's starting to make a difference!

I've noticed that along with the Focus product I'm less stressed and have not been sweating the little things like I used to. I feel it's working. Am sleeping better as well.

I love this product!

I love this product!

Great Product

Was struggling with irritability and this helps me feel so much better.

Helps Me Sleep

I do like this product a lot. I bought it for my husband (haha) but tried it for a bit and felt like my mood was better and my sleep was more restful.

Great product!!!

Helped me with my worries and gave me very good night rest!!!

Not giving up this helpful product!

Noticed a difference in how I felt within 4 days of my initial trial on Serotonin Mood Support nearly a year ago. Was suffering with moderate to severe low mood at the time and this product has been life changing for me. I can miss a dose and be fine.

Thank you, Dr. Amen! Thank you!

I’m a regular person who is going through a lot in life but now, thanks to taking Serotonin Mood Support, my negative thoughts are gone, energy is better, and self-esteem is way up!! Thank you, Dr. Amen!

Has helped with sadness and melancholy

I have struggled with sadness and negative thoughts since childhood and have tried other products. I wanted to live a more healthier lifestyle and try natural supplements to help me with my sadness and melancholy, so I have been using the serotonin mood support supplement and find it helps me with my sadness.

Great product!

This is a great product! I use it as directed and feel much more peaceful in general throughout the day. Taking it along with Focus & Energy and Brain & Memory Power Boost has improved many aspects of my life, especially not feeling so agitated and able to make better decisions.

I use it to feel better in a natural way

Made a huge difference in my mood.

Great overall

Best 5 htp in the market!!! It took a few weeks for it to start working for me.

This is great for those with a hormonal imbalance.

I could tell a noticeable difference when taking this product. I have had blood tests done that show my hormonal imbalances and I have very very low serotonin levels. This helps without any bad side effects.

great product

It is calming and soothing

Not mood-altering, mood-support and stability.

I think I have always been low in Serotonin. I have received support from 5-HTP and from Tryptophan and from Rhodiola. I really like this product because it is an all-around support. I rely upon it to help me stay even and upbeat.

Great for switching gears

Been taking Serotonin Mood Support for about a month now and can notice shifts in my thought processes. Usually I would get stuck on a subject, emotion, or situation for a while. Now I have been able to switch gears in order to get refocused on what is in my present moment.

I would HIGHLY recommend this product to anyone in need of CALM and PEACE! I will be taking this product as needed, and it could be a good idea to keep it on hand!

When I first started to take this product, I was amazed at how quickly my body (and brain!) responded. I had been under a tremendous amount of stress and needed CALM in a HURRY! The Serotonin Mood Support did not let me down! I had wonderful peace and calm and was able to deal with the stress so much better - wow ! I took this product for about 2-3 months, then found myself being TOO calm and so I discontinued using it. I did find that I would get mildly nauseous from this product but it was not intolerable and the benefits far outweighed the minor side effects. I have tried other 5-HTP products, and they definitely do not give the same results. Dr. Amen knows how to design the right combinations for the best results.

Love it

This product has changed my mood instantly. I love how much happier I feel with a natural supplement like this one.


I have been using this product for several months. I take 2 caps in the am and find that I feel good all day. Sometimes when I wake up, I feel out of sorts, fussy and irritable. This is the perfect help for me. I will continue to use this product. Thank you Dr. Amen for all that you are teaching us.

It has helped me abundantly

I love this product!

Great product

My general mood is more level with generally a more relaxed feeling of contentment. Little things bother me less and it feels like I am more balanced than before using this product.

Good supplement

As usual, Dr. Amen does not disappoint. The supplement does what it's intended to do. I take this after a long day of work - when it's time to unwind.


I am have struggled with a low mood, but since starting these supplements, along with Focus and Energy, I feel more like myself. I have a long way to go but feel I'm headed in the right direction with these supplements.

It works!!

I take this every night before going to bed. People describe me as an upbeat person, but I noticed last winter that I was less positive, less patient and finding life too challenging. I have been taking this supplement for six months now. It has brought the old me back!!

Excellent buy! Does exactly what it says in a short period of time.

Without a doubt, I will give this 5 stars! I am from Barbados presently going through menopause and my mood has been like a roller coaster. Also, my appetite has been increased with cravings for sweets. It only took 2 weeks for me to notice a drastic change in my moods. I am calmer and not as irritated and stressed as I use to be prior to taking these tablets. My husband even commented on my calm behavior and I told him it has to be the tablets. I am not having cravings like before for sweets and I do not feel to eat as often and as much like before. This is a life time buy for me. It's worth every cent and it truly brings happiness!

Not bad.

Has a calming feeling without any drowsy or noticeable slow down effect. Although it is a little too pricey for my personal liking.

Serotonin Mood Support helped me feel better

I have struggled with negative thoughts and feeling "blue". This supplement seems to help keep my mood uplifted and I feel so much more productive and focused. Highly recommend trying this.

A Hug All Day!!

I ordered Serotonin Mood Support for my husband and it has helped his mood so much! He struggles with a low mood here and there. Since he started taking these he has noticeably felt much better with a happier mood that is more consistent. He refers to his Serotonin Mood Support as his “All Day Hug”, because who does not feel good when they get a hug!! ;)

Necessary part of my nervous system support. Won't be without it.

I have been trying different supplements, herbs and healing modalities since I was fourteen in order to help regulate my mood, energy and mental focus. NeuroLink is the first product from the Amen Clinic that I used. After only a couple of days I noticed I was less anxious. I added ashwaganda and another ayurvedic herb and after a few weeks had more energy without feeling stimulated. After a few days of adding Serotonin Mood Support, I noticed that I was feeling less horrible. Horrible was my normal for most of my life. Now, after two weeks of adding the Serotonin Mood Support, some days I actually feel what I imagine "normal" people with regulated nervous systems feel. Sometimes I even feel cheerful for no particular reason. I can't say this supplement on its own is the solution but it certainly is an important element and I recommend it to anyone who is suffering with low mood and worries. I suggest combining it with the NeuroLink. Don't give up hope. It took decades for me to find a combo that works.

This product is amazing

This has helped me so much and my mood is 100% better.

Wow! Just wow!

Ordered my dad this product who is suffering from high levels of worries and is very moody. He tried the product and feels emotionally regulated and experiences mental clarity at the same time. Wow! Just Wow!

A welcome gift from God

After taking Serotonin Mood Support for the past 3 months, I stand amazed at the difference it has made in my demeanor and overall well-being. For so many years, I had very little reason to look forward to the next day as well as the rest of my life. I was hopeless and helpless with no real reason for being alive. But this supplement has helped me find reason to look forward to what lies ahead. I thank God & Dr. Amen for providing a way out from the low state I was hopelessly trapped in. I can never thank you enough for all you've done & what you mean to me Dr. Amen. Your friend & loyal customer for life, Clyde Glenn

Fantastic results

My daughter has been taking Serotonin Mood Support for just over a month in combination with GABA Calming Support. Her extreme rage behaviors have almost completely stopped, and when she does get upset, she is able to regroup and turn it around in a fraction of the time. This supplement is amazing in my honest opinion.

Glad I was watching KQED to learn about the Amen Clinic

I was searching for a solution to my moods, energy, and menopause issues. I turned on KQED and listened to Daniel and Tana program. I joined that night to see if this program would work for me. I do not have a major weight issue (15 lbs. to lose) but focus along with memory loss was making me question myself. I have loved all the DVDs, The Warrior Way reading book and cook book, plus access to the Amen Clinic website. One month ago, I purchased the multi vitamin and serotonin product. I am experiencing my past life which was (and is now) with less brain fog, more energy, staying calmer, and eating much healthier.

Happier and Calmer

My husband began taking these a few weeks ago to help with the stress of his job, and he immediately noticed a difference. When crises occurred (as they often do in his line of work), he told me he felt calmer and even better able to emotionally handle the situations than before. We initially tried these because of the free trial, but we have now begun to regularly order them.

Wrong product for me

May be a good product but not for me. I was a nervous wreck by day four. I need the GABA not this product

helping me let the little things go

Started taking serotonin with the brain and body power early March 2017 and noticed a significant difference in my ability to cope with the little stresses of everyday and the bigger stresses to some degree. Could not take the full dosage though due to the cost but I did notice an improvement over all.

Serotonin Mood Support is a life changer.

This product was the first AMEN product I ordered, after taking the Web Neuro test. I knew I was low on serotonin, but did not know of a natural source. Relief! Within days, I could tell that this was going to make a huge difference. I feel very fortunate to have the Brain MD line to help with a lengthy battle with my mood and worries! Thank you!

Love it, it really works!

I have trouble with seasonal mood issues, and normally adding some D3 and B vitamins do the trick but not this year, so I was reading about what the Serotonin Mood Support helped with and gave it a try. I have found it to help. I don't feel so moody or stuck in my head; negative thoughts and feelings running over and over.

One of my favorite Brain Health suppliments

Calming mood was the first thing I noticed, I was surprised how quickly it took effect. I realized that my decision making at work was much more controlled due to being relaxed and clear minded.

no more just getting by

I can't tell you how much better I feel on this supplement. I have energy and I feel like I have my real self back. I was going through the motions to get through my day but not anymore.

It works well for me...

I am taking the multi vitamin along with this & I see an improvement with my mood. I am more relaxed & seem to be clearer minded. I would recommend this product to anyone who seems to be cloudy minded, sad & unfocused...

For the "Cingulate from Hell"

I have what Dr. Amen refers to as the "cingulate from hell," which is no exaggeration. After taking this supplement consistently, things are significantly less hellish.

Works great

My son takes this for his mood and worries. It took about 3 weeks before we saw positive results. It's surprising to me how well this works.

Study his work and apply it to your life as much as possible. Naturally keep open mind and compare.

Mother (100 years old) and myself (72) have been using this product to deal with stress in our lives. We are very pleased. We do not fully understand the product. I have studied Amen's home study course material. I am dually impressed with his and Tana's work. I wish I could afford to go to clinic for full workups for both of us. I will follow his dietary and supplementation recommendations as closely as possible. I think he is the best. Unfortunately, I cannot afford the best every day.

Love these!

Love this supplement!

It's Better... Way better!

I started using Amen Clinic’s Serotonin Mood Support to help with my mood. It's better... way better!

Noticed an immediate difference

I noticed an immediate difference within 3 days. My affect has been much more even and calm and no episodes of "stress eating".

Good stuff

The biggest difference I noticed was with my appetite. I don't have the desire to eat excessively anymore and I stopped having sugar cravings about 90% of the time. I'm glad BrainMD Health came out with the chocolate bars to cover me the other 10%. :)

I like this this item, it does what it says it will do.

Although I only tried the 7 day trial I will say that I experienced a difference in my mood. I found myself to be much calmer when hit with stressful situations at work. I decided to move up to another Brain MD item that supports mood but also focus and retention. I think these supplements are made up of excellent quality!

Works great!!!

It really helps boost my mood! Great supplement to try when feeling blue. Combine with a healthy diet and you will see even more benefit!!

My son seems happier

My son started taking this with several of the other supplements. He says they are helping him. His mood seems to have elevated a bit after just a couple of days.

So far so good

I've only been taking it for 3 days now but I can feel a difference in my mood. So far no mood swings or feeling worried or sad.

Immediate changes

I started to taking the supplements slowly, half the recommended dose. I've found through trial and error that it is the best way to introduce supplements into my body. After the third day I felt a bit of pressure in my head but I knew it was the supplement. I also felt upbeat and started doing things I usually put off. Still too early to say for sure but so far I like what I feel and I'm very hopeful.

This product actually works! Thank you Dr Amen!

I would not be without this product!

A Great Way to Feel Happier!

On the first or second day, I noticed results. My mood was at an even keel, and I started feeling happier, apparently for no reason at all. I hate my job, so for me to be happy on the job is rare. Even if I didn't get enough sleep, I still felt better, although getting enough sleep is critical in maintaining a balanced mood and outlook on life. I would recommend this product. It's pricey, can't say I would order on a regular basis for that reason, however it is worth the money.

Wonderful Supplement.

My husband has a bit of ups and downs. I started him on this supplement and immediately it calmed his jitters. He has been much more relaxed and thoughtful in everything. I have also been using it for grief after my sisters passing. It has helped a lot.

Adult ADHD

This supplement has a well-rounded base of supplements that were recommended for my husband. The mix of B vitamins with 5-HTP provide a recognizable difference in his mood and ability to keep the negative thoughts at bay.

Noticed a more positive outlook and less fatigue

I have noticed a positive change in myself since introducing these supplements. I however need to do several "introduction and elimination" experiments before I can conclude that the positive changes are due to the supplement and not other factors. Therefore only 4-star rating for now. Will write a follow up review.

Serotonin Mood Support has been a great gift for me. I eat better and sleep well without waking up agitated and hungry. I feel normal again.

Since taking Serotonin Mood Support I have stopped eating sweet foods that were wrong for me. Before taking Serotonin Mood Support I never slept the night through, now I get a healthy 7 to 8 hrs easily. I wake up in a normal state of mind instead of feeling too worried to get out of bed. With Serotonin Mood Support I feel normal again.

HIGHLY recommend!

We added this product a month into our regimen for my daughter who had visited the Amen Clinic. I am her mother. I decided to try the product and was extremely pleased with the results. I found that only 1 pill per day gave me a little pep in my step. I ended up ordering myself a bottle and I am so glad I did!

Did not work for me.

This product did not work for me. It made me really sick and dizzy.

Helps me with my mood and worries!

This works better than anything I've tried without all the side effects. I can't recommend it highly enough! If I had to buy all of the ingredients separately, I'd have spent a lot more money. This way, I get them all in one convenient formula. This product has helped with my "burnout" and helps keep me calm and my mood lifted throughout the day. I also take Brain and Body Power and Craving Control as well.

Serotonin Mood Support

Serotonin mood support has helped not only myself but others that I coach that have issues with behavior/moods/hot flashes. I've come to love this holistic supplement and the effects it offers behavior. In this world of stressful living and not slowing down not counting the countless electronic devices that are attached to our everyday living, it brings calmness to the world that brings us to our daily rushing around. I couldn't imagine trying to do all the daily tasks without this and I know that my brain is loving the calmness it brings as well as brings my clients.

Reducing my impulsiveness

This has really been a help to me in reducing impulsiveness and providing more focus.

This is a great product.

I bought Serotonin Mood Support for my son's girlfriend. She is on her third bottle!! She loves it. She has struggled with her mood in the past. I am today setting up a monthly automatic send out. This is a great product.

very pleased.....will never be without this product

Great product!! With this and the Brain/Body supplements I feel so much better. I keep my bottles at work, in my purse, and my night stand so that I always take one when the time calls for it. It really supports me feeling more balanced and positive.

Recommend to take.

I feel much better when taking Serotonin Mood Support instead of 5-HTP, which I took for almost a year, with relatively low improvement. The cost is higher though, but with better effectiveness. You can store more when there are sales.

This product really works for me & has contributed to a better overall sense of well being.

This product really works for me & has contributed to a better overall sense of well being.

All in all a great product for balancing mood, appetite control, and better sleep.

I take 2 in the evening. I sleep more soundly and feel much more pleasant all day. I like that the B12 and B6, which I need, are in the formula. I also feel some degree of appetite reduction.

Better than 5-HTP alone

This product is Amazing...better than just 5-HTP alone. And it's in a dose that means you can tweak your dose as needed to.

definitely positive

Keeps my mind in a more positive focused direction. Less frustration with small irritations which are inevitable.

Relieving Mood Challenges

This product has truly helped my mood. I used to have periods during the day where I would be overcome with sadness. Since I've been taking Serotonin Mood Support, those episodes have decreased significantly.

I would highly recommend this product.

Very excited to have found a natural way to assist me in managing my "burn out" symptoms. Personally I noticed a difference within 1 week. I continued to notice improvements as the weeks went on. I have also found increased success in adding 40mg of Sam-E per day to my vitamin regime.

This helps me feel relaxed and calm both day and night, works wonders with meditation and hypnosis. Loving this!

Loving the calming effect of Serotonin Mood Support.

I highly recommend this product.

We absolutely love this product in our home! My daughter is on it daily to help with her mood. I do not take this supplement daily, however when needed and feel a boost when I do.

Helps me cope with my day

I noticed a calming effect as soon as I started taking it.

Great product.

I use this with Craving Control and enjoy the calm sense of well-being and stay in control of my food choices.

AMAZING product!! It has truly helped me already and it has only been a month.

I have been taking the Serotonin Mood Support for just over a month now and it is AMAZING how quickly I have noticed a change in my attitude. The little things that use to get me down and really drag on me every day have slowly started to change. I would recommend this product to anyone who needs a little extra mood support. Awesome product!!

I use this everyday!

This product is OUTSTANDING!!!

I will buy the product again.

Since I've been taking Serotonin Mood Support, I have felt much better.


This has been a wonderful supplement to assist in keeping my mood on an even level. It was recommended by my MD to use a supplement that was similar (5HTP), and had been taking it until locating the product by Dr. Amen which also contains Vitamin B6, Folate and addition to the (5HTP): a much more effective formulation. This has assisted in keeping my mood even during a difficult day or time.

Overall Serotonin Mood Support has worked just as stated. Positive Uplifting and Calming ...all in one. For me it is amazing! Thank you Dr Amen and Staff!

My experience is very positive. I have been challenged most of my adult life with my mood. I have confronted these symptoms over the years through exercise and meditation, but recently (I am 59) the intensity of my symptoms were becoming too much to bear. My work and relationships were suffering and I wanted a natural answer. So, after I read about Serotonin Mood Support, I decided to try it. I have now been taking it for 2 weeks and there is already a noticeable difference. I am able to work through most days and feel more relaxed than I can remember. Sometimes I feel so peaceful that it feels awkward since I got so used to feeling tense and negative. I feel in this short time that I am on to something very special. Looking forward to the long run.

I like this product. It helps me feel more stable.

I feel much better mentally. It helps my mood and keeping a positive outlook on life.

Great for mood

Works well to promote positive moods. I can definitely tell a difference in my mood.


This works very well for my teenage son. It has helped his moods very much.

Great Supplement

This really has helped my mood. I didn't even realize I was off until I started taking this. It was a recommended supplement after I took the brain fit test, so I thought why not. Well now I realize that it was something I did need.

significantly improves mood

Excellent product that helps me tame my negative thoughts and supports a positive mood.

Why Wait?

Amazing! Highly, highly recommend. The results my boyfriend has gotten taking this supplement have been phenomenal to watch. Before taking Serotonin Mood Support, he was moody, extremely irritable and quick to anger and become frustrated. Now, taking Serotonin Mood Support he is not only happier everyday, he no longer experiences the mood swings and irritability he once did. His energy is much more even and has been absolutely delightful to be around every single day. :)

Love it!

I absolutely love this product! I started taking it a week or so ago and I noticed an immediate difference. My mind feels clear and sharp again! I've been able to get more accomplished and my ability to focus has returned. Thank you, Dr. Amen!

This has helped me see what is really important in life.

Really supports my positive mood.

It really works!

I feel so much happier taking these mood up-lifters. Wish I had known about them years ago!


Over the years I have tried all different strategies (e.g., cognitive therapy, diet, exercise, etc.), and other neurotransmitter supplements to deal with my mood issues. This Serotonin Mood Support supplement works the best for me in conjunction with a healthy, balanced diet, daily meditation, exercise and a mindfulness practice.

Amazing difference immediately!

I was taking a serotonin supplement from another company and never really knew if it made a difference but the Serotonin Mood Support makes a huge difference – I don't cry over spilled milk anymore. I'll never not use this supplement!

Serotonin Mood Support

Helps support a positive mood.

helpful supplement

I started using this along with NeuroLink for my son. It seems to already be helping his negative thoughts and words.

Less stress

My son has fewer mood swings. He is more calm as he deals with stress in a college environment.

A superior product with no negatives and huge positives!

As Dr. A suggests – find the least toxic, most effective help. He was so right! This product made a huge difference between feeling down -- and feeling a sense of well being. I was so happy to share this product with a loved one!

Excellent product

Very good product. Helps me to relax after a stressful day and be able to sleep better. Still not sleeping through the night, but I am only taking 1/2 the recommended dosage as it is only a 2 week supply and am trying to stretch it out for a month.

Excellent supplement!

Thanks to Serotonin Mood Support for supporting my positive mood.

A supplement which delivers! Would not do without it!

I can say without equivocation that this product makes a magnificent difference with respect to sleep issues, outlook, and general feelings of wellbeing.

It is working!

I started to feel better as soon as I started to use the product. I noticed that now I am easily falling asleep and my mood is more balanced.

Excellent product

This is for my grandson who can tell the difference when he is without this supplement, so he never forgets to take it.

The herbal and vitamin pairing that makes the day!

I am so glad to have this as part of my daytime regimen. I am a fan of herbal remedies and like the use of saffron and folate as part of a total calming "recipe", if you will. These herbs seem to team up with the B vitamins to relax me from different angles. My thought processes seem more "matter of fact" and come from a natural, relaxed frame of mind. I will keep using this to keep the improvement growing.

Good mood

Good product to overcome consistent down feeling, helps to keep me focused on the positive things. Also notice it helps keep my eating under control

Serotonin Mood support

I started taking the Serotonin mood support and it has definitely made a difference in my mood. Not as irritable or moody.

Relief For My Overactive Brain

Knowing how valuable sleep is for my health and healing, I have created even more stress and anxiety, especially at night. The "LOOPS" have been the most noticeable road block. Now, most of the time, I notice a "loop" and can just tell myself to stop and I shift easily away from it. After many years of meditation, trying to get some control over my runaway mind, I finally have some healthy control. I am taking this in conjunction with several other of Dr. Amen's products and will continue as my overall health improves as my dear brain settles.


I have been struggling with mood issues since I was a teen. BrainMD Health's Serotonin Mood Support has given me hope. My mood has been "online" and my ability to fight the ANTS is soooo much improved.

Serotonin PLUS!

My husband had been using over the counter Serotonin to help him sleep which helped some, enough so that we were 'satisfied' with it. We switched to this Serotonin Mood Support and it's proven to be so much more effective.

Very helpful

This is a very good product. It has helped me a lot.

Already Working

I've only taken the supplement for a week but I already can feel a difference. I am going to sleep faster and I feel more rested when I awake. I'm also better able to control my eating urges. My moods seem to have stabilized. I am excited to learn how I will feel after taking the supplement for a month or longer.


This product has helped me with my mood and social engagement.

Excellent results

I have tried other supplements to help with my mood and they were not working. This one seems to give me more of a positive mood throughout the day. I am very pleased with the results and would recommend it to others. I would like to see it come in a bigger bottle. hint hint.

Stable mood, better sleep, more happy !

I am taking this supplement for 2 weeks already, I am was amazed to see results the 1st day. I remember the 1st day, I had a terrible day, was exhausted, and very mad for many problems that happened that day, including an almost car accident ( i was in a taxi). my family was waiting for me and also had to visit my parents that day, I was in a terrible mood, I felt anxious trying to go back to feel good but was impossible, then I saw the serotonin mood support in me desk and I took 2 vitamins, after less than 2 hours I saw a smile in my face, no angriness, I was feeling good. Couldn't believe it. I had a great time with my family and parents. from that day I take it daily and I feel really good. I sleep better and longer (7 hours), I am more patient, I smile more, feel more relax.

Has been helpful

My son has been taking this supplement for about a year and I can definitely see a positive difference in his mood.

This supplement is great! It really works!

I use the GABA calming and the Serotonin mood support at night and has me sleeping fabulously. I have a hard time winding down at night but this supplement does exactly what it says it does. Two thumbs up!!!


This supplement is amazing how efficiently and completely it helps to calm without feeling foggy or like you have "medicine head" after taking it. My husband and I don't miss a day!

Sleep better

I have been sleeping better and don't feel so tired in the morning. I also feel more relaxed in the day.

Trading for Anti-Depressants

In the process of taking down my antidepressant doses and replacing with these. So far so good.

So much improvement!

I use Serotonin Mood Support with NeuroVite Plus, GABA Calming Support, and Omega-3 Power and I saw so much improvement in just a week. I am able to sleep better, control negative thoughts better, and think more clearly. I don't have the anger outbursts I used to have and I just have a better mood in general.

Less reactive and stable moods

Since taking Serotonin Mood Support, I find myself with stable moods and less reactive to situations.

Feeling Better Lighter Happier

I just bought one bottle and wondered how things would progress as I am generally hopeful and also realistic. Well I was very pleasantly surprised to discover that the Serotonin Mood Support supplement really does work. I would like to see it in a more affordable supply! 3 weeks of supplement for $45 is pretty steep even if it does make you feel better the weight of the cost does drag one down somewhat. Seems silly too, that you can't buy a larger supply for less money... hint hint. I will be buying more without a doubt and definitely recommend them.

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Ingredients & Facts

  • Vitamin B6
    This water-soluble vitamin is essential for at least 100 enzymes that help the body utilize amino acids, fatty acids, and carbohydrates. It is also essential for aiding the production of serotonin and other brain neurotransmitters. Vitamin B6 is also vital for early brain development and for supporting the body’s innate antioxidant defenses. This formula provides the two chemical forms of B6 that are most fully absorbed and utilized.
  • Folate
    This formula contains Folate as Methylfolate (MTHF), which is the superior, most active and easily utilized form of this vitamin. Your body needs folate to make and repair DNA. Meanwhile, the brain specifically requires MTHF to make neurotransmitters, to produce the myelin insulation of nerve cells, and to make the sleep hormone melatonin. It also helps the liver and other organs recycle the metabolic product homocysteine, to prevent it from building up to toxic levels.
  • Vitamin B12
    This vitamin is essential for structural integrity of the brain and spinal cord. It works very closely with folate to power key enzymes that recycle homocysteine. Methyl-B12 is fully activated B12 and is superior to cyano-B12 (cyano-cobalamin), which contains potentially harmful cyanide and is found in many multivitamins. Vegetarians, vegans, smokers, people taking certain over-the-counter medications, and the elderly are at risk of vitamin B12 deficiency.

    Higher levels of B12 are linked to better control over mood, behavior, personality and mental clarity. The high dosage of methyl-B12 in this formula helps ensure its efficient delivery to the tissues, and sets Serotonin Mood Support apart from other supplements that supply measly doses of B12.
  • Satiereal®
    Satiereal® is a patented extract of saffron, which grows mainly in Europe and the Middle East and has been used traditionally to aid in digestion of spicy food, soothe an irritated stomach and support a healthy mood. Scientists believe saffron may increase serotonin levels in the brain. Saffron contains 4 compounds that have powerful antioxidant, brain-protective, and serotonin-enhancing actions. A number of clinical trials validated saffron’s mood benefits, while further trials have established it also has benefits for memory.

    Satiereal® was found to reduce food cravings and other inappropriate food habits in clinical trials. It reduced feelings of hunger and lowered frequency of snacking, supporting appetite moderation and healthy weight management.
  • 5-HTP
    This metabolite is naturally made in the brain, which converts it to serotonin as needed. 5-HTP promotes calm, positive mood, relaxation and healthy sleep. The 5-HTP included in Serotonin Mood Support was extracted from the African plant Griffonia simplicifolia.
Supplement Facts
Serving Size 4 Capsules
Servings Per Container 30
Amount Per Serving % DV
Vitamin B6
(as pyridoxine HCl & pyridoxal-5-phosphate)
20 mg 1000%
(as Quatrefolic® 5-methyltetrahydrofolate, glucosamine salt)
400 mcg 100%
Vitamin B12
(as methylcobalamin)
500 mcg 8333%
Satiereal® saffron
(Crocus sativus) stigma extract [standardized to 0.3% safranal]
177 mg
5-Hydroxytryptophan (5-HTP)
(from Griffonia simplicifolia, seed)
100 mg
† Daily Value (DV) not established.
Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, magnesium stearate, silicon dioxide.

Free from milk/dairy, gluten, wheat, yeast, eggs, corn, artificial colors or flavoring.

Do not use this product if currently taking antidepressant or monoamine oxidase inhibitor medications. This product is not recommended for use in women who are nursing or pregnant.

Dr. Amen talks about Serotonin Mood Support

Stop struggling with low moods

The Science

Supports calm, mood and appetite.

  • 5-HTP
    5-HTP (5-hydroxytryptophan) is an extract from the African plant Griffonia Simplicifolia, and is the precursor to the neurotransmitter serotonin, which plays a role in mood, sleep and appetite. Randomized clinical trials demonstrate the efficacy of 5-HTP supplementation supporting a healthy mood. 1,2
    1. Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian journal of psychiatry. Feb 2013;6(1):29-34.
    2. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002(1):CD003198.
  • Satiereal®
    Satiereal® is an extract of saffron (crocus sativus) and has been shown to improve mood states by modulating levels of neurotransmitters in the brain, including serotonin.1-3 Saffron is grown in Iran, Greece, Spain and Italy and traditionally has a long history of use to ease the digestion of spicy food, to soothe an irritated stomach and support a healthy mood. It has been found to have strong antioxidant and free radical scavenging properties.4 Randomized controlled trials of Satiereal demonstrate improved outcomes on mood and behavior.5-8
    1. Hausenblas HA, Heekin K, Mutchie HL, Anton S. A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. Journal of integrative medicine. Jul 2015;13(4):231-240.
    2. Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Human psychopharmacology. Nov 2014;29(6):517-527.
    3. Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Journal of integrative medicine. Nov 2013;11(6):377-383.
    4. Srivastava R, Ahmed H, Dixit RK, Dharamveer, Saraf SA. Crocus sativus L.: A comprehensive review. Pharmacognosy reviews. Jul 2010;4(8):200-208.
    5. Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. Nov 2006;13(9-10):607-611.
    6. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC complementary and alternative medicine. Sep 2 2004;4:12.
    7. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytotherapy research : PTR. Feb 2005;19(2):148-151.
    8. Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry. Mar 30 2007;31(2):439-442.
  • Folate (as Quatrefolic® methylfolate, 5-MTHF) (5-methyltetrahydrofolate, glucosamine salt)
    This formula contains Folate as Methylfolate (MTHF), which is the superior, most active and easily utilized form of this vitamin. Your body needs folate to make and repair DNA. Meanwhile, the brain specifically requires MTHF to make neurotransmitters, to produce the myelin insulation of nerve cells, and to make the sleep hormone melatonin. It also helps the liver and other organs recycle the metabolic product homocysteine, to prevent it from building up to toxic levels.
  • Vitamin B6 (as pyridoxine hydrochloride and pyridoxal-5-phosphate)
    This water-soluble vitamin is essential for at least 100 enzymes that help the body utilize amino acids, fatty acids, and carbohydrates. It is also essential for aiding the production of serotonin and other brain neurotransmitters. Vitamin B6 is also vital for early brain development and for supporting the body’s innate antioxidant defenses. This formula provides the two chemical forms of B6 that are most fully absorbed and utilized.
  • Vitamin B12 (as methylcobalamin or methyl-B12)
    This vitamin is essential for structural integrity of the brain and spinal cord. It works very closely with folate to power key enzymes that recycle homocysteine. Methyl-B12 is fully activated B12 and is superior to cyano-B12 (cyano-cobalamin), which contains potentially harmful cyanide and is found in many multivitamins. Vegetarians, vegans, smokers, people taking certain over-the-counter medications, and the elderly are at risk of vitamin B12 deficiency.

    Higher levels of B12 are linked to better control over mood, behavior, personality and mental clarity. The high dosage of methyl-B12 in this formula helps ensure its efficient delivery to the tissues, and sets Serotonin Mood Support apart from other supplements that supply measly doses of B12.

Frequently Asked Questions

How do I take Serotonin Mood Support?
Take four capsules daily in divided doses just before meals, or as recommended by a nutritionally informed physician.
Is it best to take Serotonin Mood Support with meals?
You can take Serotonin Mood Support with or without food, but preferably it should be taken with food.
Is Serotonin Mood Support safe for long-term use?
Yes, as long as you stay within the recommended dosage. If you wish to take higher doses than we recommend, discuss your reasons in advance with your nutritionally informed physician or other qualified healthcare professional.
Can I take Serotonin Mood Support if I am taking antidepressant medication?
Do not use this product if you are currently taking antidepressant or monoamine oxidase inhibitor medications.
Can I take Serotonin Mood Support if I am nursing or pregnant?
Serotonin Mood Support is not recommended for use in women who are nursing or pregnant.
Are there other BrainMD products from Dr. Amen I should be taking?
The BrainMD Brain & Body Power and Brain & Body Power MAX are superior daily supplement systems that Dr. Amen typically recommends to everyone. They represent the current state of the medical science for comprehensive protection of mind and body. Each includes over 50 vitamins, essential minerals, a very generous allowance of omega-3 DHA and EPA, phytonutrients, along with proprietary mixes of clinically researched brain boosting nutrients and fruit concentrates, all helped down by digestive enzymes. Each comes in handy packets that are easy to take along wherever you go, and by taking just two packets daily you are well covered by “nutritional health insurance.”

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