Better brain chemistry = better quality of life
Proper neurotransmitter balance essential for optimal brain function. Do you ever feel sad or irritable for no reason? What about feeling anxious or worried? Unfocused? All these can be linked to brain neurotransmitters being out of whack. NeuroLink provides an exclusive blend of nutrients that support such key transmitters as adrenaline, noradrenaline, dopamine, GABA, glutamate, and serotonin.
Fires up brain synapses
The brain’s billions of nerve cells make trillions of connections with each other. These are called synapses. Each nerve cell generates electrical signals that travel as far as a synapse, where a chemical signal then bridges the gap between that cell and the next. These chemical signals are carried by specific messenger substances called neurotransmitters (or simply "transmitters").
Different nerve cells make different sets of transmitters, and the intensities and patterns of transmitter releases help determine the brain’s cognitive, mood, behavioral and personality expression. The better our transmitters operate in balance with each other, the closer we are to having optimal mental function. NeuroLink supports a diverse array of transmitters important for positive outlook, relaxation, coping with occasional feelings of anxiety, and managing stress.
Your mental state is affected greatly by your brain chemistry. When your brain transmitters are balanced you can think more clearly, feel happier, and experience greater well-being. Some people have a sunny outlook on life, but others struggle to remain positive and even-tempered from day to day. NeuroLink provides nutrients that help your brain meet its needs to sustain optimal levels of critical neurotransmitters and keep them in healthy balance.
Provides neurotransmitter precursors
The secret to NeuroLink’s effectiveness is the nutrients it supplies that are biochemical jumping-off points for specific transmitters. Our transmitters have to be made from substances that ultimately are obtained from our foods or from dietary supplements. NeuroLink provides a select combination of nutrients that the brain requires to make key transmitters. These have to be in good balance for the individual to have emotional balance, calm, focus, and a stable mood.
Dr. Amen talks about NeuroLink
Balanced brain chemistry... naturally.
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Ingredients & Facts
NeuroLink delivers six powerful brain-balancing ingredients:
Vitamin B6 (as Pyridoxal-5-Phosphate)
Vitamin B6 (of which pyridoxal-5-phosphate is it most active form) is a water-soluble vitamin essential in the production of various neurotransmitters and their actions at the synapses. It is also essential for early brain development. It is required by at least 100 enzymes that help the body utilize amino acids, fatty acids, and carbohydrates, and helps supports the body’s antioxidant defense enzyme network.
Tyrosine is an amino acid required for the production of the neurotransmitters dopamine, and of epinephrine and norepinephrine that are derived from dopamine. The adrenal glands work together with the brain to manage stress, and also use tyrosine to make these same three transmitters. Tyrosine is also needed by the thyroid gland to make the hormone thyroxine, and the skin needs it to make melanin. Having sufficient tyrosine in the brain promotes mental clarity in dealing with stress.
GABA (Gamma-AminoButyric Acid)
This amino acid regulates excitability of nerve circuits in the brain, and is considered the brain’s main “calming” neurotransmitter. Its importance for the brain begins before birth, as it regulates the proliferation, positioning, maturation, and wiring together of the nerve cells. In adults, GABA helps regulate the activity of synapses but also remains important for the maturation of new nerve cells (neurogenesis). GABA deficits are associated with brain hyperexcitability, untypical behavior, cognitive difficulties, and mood challenges.
This amino acid is important for the brain to make both glutamate, which is an excitatory neurotransmitter, and the calming transmitter GABA. Glutamate is a near-universal neurotransmitter, present in 80 percent of the brain’s nerve cells. It is an important regulator of learning and memory processes at the level of the synapses. Support cells in the brain work with the nerve cells to assure constant and controlled availability of glutamate. Glutamate also seems centrally involved in healthy mood management.
Taurine is an amino acid unique for not becoming incorporated into proteins. Instead it fulfills important regulatory roles in the brain, the eyes, and the other organs. It is essential for early brain and eye development, and is concentrated in the breast milk. All through life, taurine helps stabilize our nerve cell electrical activity and provides all our cells with osmotic protection by preventing them from swelling with water and bursting. It helps protect against calcium overload that can kill brain cells. It is essential for the healthy functioning of mitochondria, the tiny energy generators of all our cells. Taurine also promotes optimal performance of the GABA and glutamate transmitter systems.
This is a modified amino acid that also is not part of proteins. It is conveniently extracted from the seeds of the Griffonia simplicifolia plant. In the brain 5-HTP is readily converted to serotonin, to help maintain mental and emotional wellbeing, reduce occasional feelings of anxiety, support behavioral self-control, promote calm and relaxation, and facilitate going to sleep. 5-HTP is also a powerful brain antioxidant.
GABA or gamma-aminobutyric acid is an amino acid that regulates excitability of the brain through GABA receptors. It is essential for brain metabolism and functions to decrease neuronal activity and inhibit nerve cells from excess firing. GABA has mild relaxation properties and can enhance mood and support sleep. Clinical studies on GABA are limited but electroencephalogram (EEG) studies demonstrate the efficacy of GABA supplementation on increasing alpha band brain wave function, which serves to induce relaxation and alleviate stress.1,2
- Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. Journal of physiological anthropology. 2012;31:28.
- Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-208.
5-HTP (5-hydroxytryptophan) is an extract from the African plant Griffonia Simplicifolia, and is the precursor to the neurotransmitter serotonin, which plays a role in mood, sleep and appetite. Randomized clinical trials demonstrate the efficacy of 5-HTP supplementation supporting a healthy mood.1,2
- Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian journal of psychiatry. Feb 2013;6(1):29-34.
- Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002(1):CD003198.
L-tyrosine is an amino acid important in the synthesis of brain neurotransmitters. It is the precursor to the brain catecholamines norepinephrine and dopamine which are important in balancing mood and energy. It is also helpful in the process of producing thyroid hormones, which are important in metabolism. Tyrosine supplementation has been shown to improve cognitive performance in healthy individuals1-3 as well as those under periods of stress and fatigue.4-8 Stress tends to deplete the neurotransmitter norepinephrine, and tyrosine is the amino acid building block to replenish it.
- Hase A, Jung SE, aan het Rot M. Behavioral and cognitive effects of tyrosine intake in healthy human adults. Pharmacology, biochemistry, and behavior. Jun 2015;133:1-6.
- Colzato LS, de Haan AM, Hommel B. Food for creativity: tyrosine promotes deep thinking. Psychological research. Sep 2015;79(5):709-714.
- Colzato LS, Jongkees BJ, Sellaro R, Hommel B. Working memory reloaded: tyrosine repletes updating in the N-back task. Frontiers in behavioral neuroscience. 2013;7:200.
- Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & behavior. Nov 23 2007;92(4):575-582.
- Lieberman HR. Nutrition, brain function and cognitive performance. Appetite. Jun 2003;40(3):245-254.
- Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. Jan 15 1999;48(2):203-209.
- Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine. Apr 1995;66(4):313-319.
- Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-323.
Taurine is an amino acid that functions to stabilize nerve cell membranes by regulating the flow of information in and out of cells. Animal studies demonstrate that taurine has been shown to help with memory and thinking skills1 and as well as reducing anxiety,1,2 which suggests it can support a healthy mood and cognition. Taurine promotes relaxation by helping to balance GABA, the brains calming neurotransmitter.
- El Idrissi A. Taurine improves learning and retention in aged mice. Neurosci Lett. May 2 2008;436(1):19-22.
- Kong WX, Chen SW, Li YL, et al. Effects of taurine on rat behaviors in three anxiety models. Pharmacology, biochemistry, and behavior. Feb 2006;83(2):271-276.
Vitamin B6 (pyridoxine) is a water-soluble vitamin essential in the metabolic pathways of amino acids, glucose, and fatty acids and is a cofactor in the production of neurotransmitters including serotonin, epinephrine, norepinephrine, and GABA. It is required by the nervous system and is needed for normal brain function as well as DNA synthesis. Supplementation with Vitamin B6 alone and in combination with other nutrients has been shown to be helpful to improve attention in children.1-4
- Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnesium research : official organ of the International Society for the Development of Research on Magnesium. Mar 2006;19(1):46-52.
- Mousain-Bosc M, Roche M, Rapin J, Bali JP. Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. J Am Coll Nutr. Oct 2004;23(5):545S-548S.
- Kidd PM. Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management. Alternative medicine review : a journal of clinical therapeutic. Oct 2000;5(5):402-428.
- Coleman M, Steinberg G, Tippett J, et al. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate. Biol Psychiatry. Oct 1979;14(5):741-751.
L-glutamine is an amino acid important in the synthesis of the excitatory neurotransmitter glutamate and the inhibitor neurotransmitter GABA. It is also a nutrient for the brain as it is used for energy if the brain does not have enough glucose to function.