SAMe Mood and Movement 400

SAMe Mood & Movement 400 provides SAMe (S-AdenosylMethionine), a nutrient with very high energy that helps power numerous enzymes important for the brain, joints, liver, muscles, and other organs. SAMe is fundamental to the body's renewal, repair and overall well-being.


SAMe Mood and Movement 400

High-Energy Metabolic Factor, Highest Purity and Stability Available

Promotes Positive Mood
S-AdenosylMethionine (SAMe) occurs naturally in our cells and has been intensively researched. This small molecule has a huge energy charge that powers over 200 enzymes necessary for healthy cell growth, maturation, and specialization. In the brain, SAMe is required for nerve cells to make energy, maintain connectivity, and generate mood-related neurotransmitters. Data from numerous clinical trials indicate SAMe strongly promotes positive mood.

Premier Source of All-Important METHYL, and SULFUR
SAMe's ultra-energized methyl group drives enzyme transformations of DNA, amino acids, proteins, fatty acids, phospholipids, polyamines, and numerous other metabolic factors that make us human. SAMe also carries energized sulfur, a mineral essential for antioxidant defense, for many metabolic pathways, and for the structural integrity of collagen and other proteins.

Promotes Joint Comfort and Mobility
In controlled clinical trials, SAMe has consistently improved human joint health, including joint comfort and mobility. Freedom of movement promotes more positive mood, and taking SAMe promotes both. This product helps maintain the body's SAMe supplies, which are subject to depletion by pharmaceutical use, toxins, or metabolic decline associated with aging.

Supports Liver Health
The liver is the main organ that makes SAMe, to keep up with the body's high need for it. Dietary insufficiencies, medications and toxins can deplete the body's SAMe reserves and further challenge the liver's capacity to make enough SAMe. But also, SAMe metabolism is tightly linked with antioxidant metabolism so that factors which drain our antioxidants also can "burn" our SAMe, and vice versa. Supplementing with SAMe Mood & Movement helps protect both liver and whole-body health.


I have set up an auto monthly order because I feel so much better

Taking Same has given me more energy,a brighter outlook,uplifted mood and less arthritic pain in my hands and feet.

good product but very high price.

My son has been taking this for a month and a half now and I can tell it has really helped with his moods, the only reason I gave it a 4 star is because I have found this exact product somewhere else for half the cost. :( Sad that you have to boost the price up so much. Most people who cannot afford such a cost. Please reconsider your pricing for others. Thank you.


This product works. I feel even keeled throughout the day. I struggle with mood challenges, and periodically get in a funk. While I'm taking this product, I notice my mood remains more stable.

Energy & Mood Improvement

It gives me more energy without caffeine; helps me feel better (like the other day I took it before a wedding because I had a bad cold). & I felt great during the wedding; or wasn't focusing on being sick? Maybe a combination of both.

Worthless so far. I may continue for a short while, but it is expensive.

I have noticed nothing in a month of use-including several weeks adding the Betaine product. In fact, I haven't noticed any improvement from any of your products.

Better mood and patience

My mood and patience has been better with the SAMe.

So far, very good!!!

Several years ago, I tried a different brand of SAMe and found that it upset my stomach, so I stopped using it. After reading reviews and listening to the informative videos of methylation and mood support, I decided to try BrainMD SAMe along with MethylFolate and Betaine. After a couple of weeks, I am a returning customer (because I don't want to be without and miss a dose) and am well pleased with the results of this combination.

Great product, I am reordering.

I have had headaches and been feeling stressed. I tried the SAMe 400 - love it, felt better right away - no more headaches and my energy is strong.

All star supplement.

Better mood, more fluid at the gym, & increased energy (which is a must). I enjoy taking this product.

Better patience

I been taking SAMe and I have been feeling in a better mood with my kids.


Using this SAMe has helped me with my mood.

Not sure yet...

Don't feel much difference between OTC and your brand. Hard to tell. Maybe with continued use?

The best mood management product

When I start feeling blue, I feel the difference the minute I take SAMe.

Gave me a horrible headache

I have taken Sam-E at various times over the years with different levels of success. I was excited to try Dr. Amen's version as I assumed it would be the purest and most potent. Unfortunately, it gave me a splitting headache. I played around with taking it at different times during the day, with and without food - and I always ended up with a headache.

Excellent - cant live without it

I take this for mood and joints! When I get stressed from my three year old grandson, this does the trick for mood and joints!

what a difference!!!

This supplement has made a huge difference. I can say that my brain fit score and energy are different today due to this wonderful supplement.

WOWWW... it works!!! :)

I just started this less than 2 weeks ago and I have already seen improvement in all aspects of my mood and energy. It is truly a Godsend because it has an instant effect and lasts for hours. I never miss a day and take it first thing in the morning without food. I pray this will continue to get myself what I need for health, body and mind always and forever. :) You will not regret trying this. I am ordering more ASAP. Thank you and God Bless Dr. Amen :)

No noticable difference

I don't notice any difference after taking it for 3 weeks. This may be because I already take medication for mood (but not for joint pain). My prescribing doctor (for mood) did not think that this would make any difference for me, and it has not.

It's the best! I love it!

I have been taking SAMe with Betaine TMG for almost 2 months now. I feel a peace that I haven't experienced in years with this. I have also tried GABA, NeuroCalm, and Everyday Stress Relief for my anxiousness. Each of these have helped, but SAMe have a much more powerful effect for me. I love it!

An immediate improvement.

I noticed an almost immediate improvement in my mood and motivation. I have not noticed a big change in mobility but my mood had clearly elevated since I started taking this product.

It works

This helped decrease my worries and improve my mood.

Significant improvement in my mood and pain level.

I am amazed at how well this works! There is significant improvement in my mood and level of pain.

Helped my joint pain in my hips!

I have been struggling with joint pain in my hips for years. It has been such a constant issue lately that I have even been walking with limp. I have been taking SAMe Mood & Movement 400 for 3 months now and I have zero pain in my hips. I am walking almost normal again! I am so grateful for this product and definitely wont go without it!

I like the supplement and would recommend it. I take several other supplements in addition to this one and find them to be very high quality.

I like this supplement and have taken it daily for several months. It helps me to balance my mood.

Will change your life.

The Amen Clinic saved our marriage. My husband no longer has challenges with his mood and behaviors since starting the program. All of these supplements do what they say. I too have enjoyed them. We both take every opportunity to be brain warriors and share with everyone the success we have experienced. SAMe has decreased my joint pain, improved my sleep and improved my mood. I am so much more focused and productive now. Don't wait to try this product. It is so worth it.

Peace of mind

My husband started taking SAMe about 3 months ago. The reason he started it is to support the health of his liver and kidneys. He feels good about taking something that brings him peace of mind.

Much better mood

I took the Brain Type test and the results suggested I might do well with SAMe. I started taking it 2x day as well as Brain and Body Power supplements. I feel so much better. More positive and happy. Even my husband said he could tell a big difference in my mood!

I will buy the product again.

I'm using this in conjunction with the Serotonin Mood Support and have found it to be very helpful.

A powerful supplement

I am really benefiting from the use of SAMe Mood and Movement. I have numbness and pain in my feet, and pain in my spine. This supplement is noticeably helping. It also is improving my mood, as historically I have found myself feeling afraid of rejection. That is gone now, and I accept what is in a grateful way.

Add this to your toolbox

Dr. Amen and Tana came and spoke at our church. I've struggled with my mood for years, and when asked what he suggests - Dr. Amen said that if he could only do one thing - he'd suggest starting with SamE. It’s natural - non addictive - and I took it daily for two months. I didn't notice changes in my movement but at end of two months wasn't struggling with my mood so much and have backed off it for now. So nice to consider and utilize natural medicines.

helps with joint movement

Have been using this product- Sam-e for a number of years now. I notice less joint pain and have more ease of movement with taking Sam-e daily. I have a very active lifestyle for many years and was feeling tighter in my movements. This product has helped ease this stiffness and tightness- helps keep me moving!

Need Help with STRESS...It Works!

My daughter suffered from severe migraines for five years. Her pain often made her very stressed out as she would miss classes and work. After a SPECT Scan, GABA Calm and SAMe were suggested to help her particular situation. It has been great. She is doing so much better and is now able to manage stressful situations with ease. Definitely a great product.

Great value!

I love this easy to take SAMe, which is less expensive than the store bought SAMe I had been taking before! Great product!!

I don't want to be without this product!

SAMe is my happy/calming pill. Before I started taking it, I would wake up in the morning with immediate racing thoughts of all I needed to get done that day, racing negative thoughts about family and co-worker relationships, basically making myself miserable. SAMEe changed all that. Now, I put a pill beside my bed before I go to bed. I take it first thing when I wake up in the morning at 4:30 am, and my mind is calm and I am in a good mood. So much more pleasant for myself and those around me. I also take it again around 11:00 am as needed. If taken too late it in the day, it does seem to disturb my sleep.

A SAMe a day...

... is a good thing. This affordable supplement makes a difference. It's a keeper.

For those of us on budgets without deep pockets the critical supplements for me will be with me, I'll do my best to find a way to have them for their benefits. This is one of them.

I can feel the difference

I can tell when I stop taking it that I am not as level and have unhealthy cravings. I was very surprised! I only tried it because Brainfit recommended it and I did have some joint pain in my feet. Seriously, no joint pain and I don't let myself run out now. Noticeable change in mood but not extreme. Joint pain gone- amazing.

Mood and Movement for making moods better to move easier

Kind of feel this one was the kicker that worked maybe, but I'm not sure, better than others. It was after I took this that a over-all sense of well-being emerged where I felt a part of life again. Emotions can be contagious, actually they are. So if you have friends, family, or on-line contacts that tap into you as the cool person you are, then you know they can deplete you (Universal you) so you, you, you must maintain your cool by any means possible. These products are it.

However I manage it here, and it won't be easy, but on out I'll not be without.

Helping my husband

In conjuction with Neurocalm, my husband has been taking SAMe and has experiences an increased clarity -- he says he can think again and no longer feels as if he is in a "fog."

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Ingredients & Facts

  • SAMe
    SAMe (S-AdenosylMethionine) has been intensively researched for over half a century. Numerous controlled clinical trials support its benefits for mood, cognition, the joints, the liver, the gastrointestinal system, and the other organs. SAMe's high-energy methyl and sulfate groups feed into a great web of metabolic networks that range from DNA production and repair to gene regulation, mitochondrial energy generation, melatonin hormone production, neurotransmitter generation, nerve cell insulation, structural collagen in the joints and other connective tissues, liver detoxification, antioxidant defense, and healthy immune response. Supplementing with the blister-packed tablets in SAME Mood & Movement provides the S,S form of SAMe preferred by our enzymes, and helps ensure the body will have adequate SAMe for its needs. For even better results, try combining this product with Betaine TMG (coming soon) from BrainMD Health. This triple-methyl group nutrient is clinically proven to boost SAMe's brain benefits.

    “Several studies have shown that SAMe can be beneficial and might be as effective as some prescription medications used to help with mood. Some research also shows that taking SAMe might be helpful for people who do not have a good response to a prescription antidepressant.”
    –U.S. National Library of Medicine
Supplement Facts
Serving Size 1 Tablet
Servings Per Container 30
Amount Per Serving % DV
S-Adenosyl-L-Methionine (SAMe)
(as 800 mg of S-adenosyl-l-methionine tosylate disulfate p-toluensulfonate)
400 mg *
* Daily Value (DV) not established.
Other Ingredients: Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glyconate, and an eneric coating of modified cellulose, magnesium silicate, triethyl citrate and riboflavin.

Free from milk/dairy, gluten, wheat, yeast, soy, eggs, corn, sugars, or artificial colors or flavoring. SUITABLE FOR VEGANS.

CAUTION: Individuals taking antidepressant medication should consult with their prescribing physician before taking this product. If you have bipolar disease ("manic depression") or PArkinson's disease do not take this product. IF pregnant or lactating, consult your physician before using this product.

Dr. Amen talks about SAMe Mood and Movement

Get out and move with healthy joints and better moods

The Science

Promotes positive mood and emotional balance. Supports joint health and movement. Enhances energy levels without caffeine.

  • SAMe
    SAMe is a derivative of the amino acid methionine that is formed when methionine combines with adenosine triphosphate (ATP), the major source of cellular energy. SAMe is a naturally occurring molecule that serves as a major methyl donor, which is how the body protects itself on a cellular level. SAMe supports dopamine and norepinephrine synthesis in the central nervous system. Maintaining adequate levels of these foundational neurotransmitters is essential in supporting a balanced mood. Several recent randomized controlled trials have demonstrated the efficacy of SAMe in promoting a healthy mood when compared to common mood enhancing therapies or placebo.1-5 It has been demonstrated to be effective when used in combination with 5-methyltetrahyrofolate, a key foundational nutrient in neurotransmitter synthesis.2 It has also been shown to improve memory related cognitive impairment when used as an adjunct therapy in those with mood issues.3 SAMe is beneficial for joints and the connective tissue and has been shown to be effective in supporting movement and joint flexibility.6,7
    1. Sarris J, Papakostas GI, Vitolo O, Fava M, Mischoulon D. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. J Affect Disord. Aug 2014;164:76-81.
    2. Papakostas GI, Cassiello CF, Iovieno N. Folates and S-adenosylmethionine for major depressive disorder. Can J Psychiatry. Jul 2012;57(7):406-413.
    3. Levkovitz Y, Alpert JE, Brintz CE, Mischoulon D, Papakostas GI. Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. J Affect Disord. Feb 2012;136(3):1174-1178.
    4. Papakostas GI. Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder. J Clin Psychiatry. 2009;70 Suppl 5:18-22.
    5. Williams AL, Girard C, Jui D, Sabina A, Katz DL. S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. Clinical and investigative medicine. Medecine clinique et experimentale. Jun 2005;28(3):132-139.
    6. De Silva V, El-Metwally A, Ernst E, et al. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology. May 2011;50(5):911-920.
    7. Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC musculoskeletal disorders. Feb 26 2004;5:6.

Frequently Asked Questions

How do I know if I need this supplement?
If you feel short on energy, or that your body isn't working the way you'd like it to, or less than fully positive about life, SAMe is worth a try. Some people report major benefits within a week.
What's the best way to take this supplement?
It's very important to take this supplement a couple hours away from food, and to avoid chewing or crushing the tablet because that would break the enteric coating which protects the SAMe molecules against destruction by stomach acid.
How much should I take for best results?
Start with 1 tablet once or twice daily between meals, then after a week, the daily dosage can be increased to a maximum 4 tablets, as recommended by a nutritionally informed physician.
Can vegetarians take this product?
Yes, it is suitable for vegetarians and vegans.
Are there people who should not take this product?
It is not recommended for bipolar individuals, because it can increase mania. It also is not recommended for people with Parkinson's. Women who are pregnant or lactating should discuss this option with a nutritionally informed physician prior to using it.

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