Betaine TMG

Provides the nutrient betaine (trimethylglycine, TMG), which enhances SAMe for healthy mood; provides crucial methyl for DNA, brain neurotransmitters, melatonin and myelin production; and helps cells regulate their water content.


Betaine TMG

Promotes healthy mood, enhances SAMe's mood benefits, supports healthy methyl and homocysteine metabolism, important cell water regulator

Markedly Enhances the Mood Benefits of SAMe (S-AdenosylMethionine)
Betaine (trimethylglycine, TMG) occurs naturally in our cells. Taking betaine can improve SAMe's mood benefits: in a clinical trial, subjects who received SAMe (750 mg/day) plus betaine (375 mg/day) performed better than SAMe alone (800 mg/day) on measures of worry, helplessness and worthlessness, agitation, and physical efficiency.

Potent Source of Methyl Groups for Numerous Life Processes
SAMe provides methyl groups for DNA production and repair and for epigenetic gene regulation; for brain production of the hormone melatonin and the neurotransmitters dopamine, epinephrine, and norepinephrine; to insulate nerve cells for high signaling efficiency; even to make phospholipids that underpin cell structure. Betaine is a highly effective methyl donator that helps the body make and conserve SAMe.

Supports Healthy Homocysteine Metabolism
Making SAMe generates homocysteine, which can have toxic effects. Betaine readily provides methyl needed to recycle homocysteine. Betaine bypasses enzyme systems that get methyl from folate and vitamin B12 but are vulnerable to inherited gene errors. Many individuals who are unable to achieve healthy homocysteine regulation by taking folate and vitamin B12 experience success by taking betaine.

Important Molecular Tool for Regulating Cell Water Content
Regulation of water content is a survival issue for all human cells. With too little water they shrink and their enzymes can't work; with too much, they swell and can rupture. They use betaine to sensitively regulate their water content.


makes a difference

My son takes this and it seems to help him have a better day and stay more regulated.

Compliment to SAMe

I have been taking this to compliment the SAMe. Don't know the specifics that this provides but with the combination of supplements I am feeling better than better.

I will continue this product for methylation support

I tried this product because I suspected I had methylation/MTHFR problems. It increased methylation for me to the point of having detox symptoms. It is very effective for me, but I cannot take this at night due to detox. I will stay on this product and the price is great! Thank you!

Great supplement to enhance SAMe

Great supplement to enhance SAMe

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Ingredients & Facts

  • Betaine TMG
    Betaine or trimethylglycine (TMG) is integral to human metabolism and clinically proven to help the brain, liver, and other organs. This small molecule is loaded with methyl groups, and is an effective metabolic backup for SAMe (s-adenosylmethionine), which is an essential cofactor for some 200 enzymes. By helping the body conserve SAMe, betaine also helps conserve the body's antioxidant defenses, which overlap with SAMe metabolism. Betaine also is a potent means for controlling potentially toxic homocysteine. The normal (and unavoidable) metabolism of SAMe generates homocysteine, and betaine may be the most efficient means for recycling it (to methionine, which then can be used to make SAMe again). We get betaine from beets (hence its name), spinach, and a few other foods, but some individuals have low blood betaine and correspondingly show metabolic difficulties. Supplementing with Betaine TMG from BrainMD Health helps ensure that the brain and body will receive sufficient methyl to fulfill their many duties. By facilitating healthy cell water regulation, methylation and antioxidant defense this product supports fundamental human life processes.
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30
Amount Per Serving % DV
Betaine (Trimethylglycine) 1000 mg *
* Daily Value (DV) not established.
Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, magnesium stearate, silicon dioxide.

Free from milk/dairy, gluten, wheat, yeast, soy, eggs, corn, or artificial colors or flavorings.

Frequently Asked Questions

How do I know whether I need this supplement?
Inherited mutations of the enzymes that obtain methyl from folate and vitamin B12 are very common, afflicting 1 in 4 individuals of some ethnic heritages. Taking Betaine TMG helps bypass such metabolic limitations. Also, anyone who is having mood difficulties can add this supplement into their daily routine. If they are already taking SAMe they can reasonably expect its benefits will be further increased.
What's the best way to take this supplement?
Try to take Betaine TMG at least two hours after eating, otherwise components of the meal you've recently consumed can compete with it for absorption into the bloodstream.
How much should I take for best results?
A good maintenance dose is one capsule (500 mg) once or twice daily between meals. To enhance SAMe for mood, we recommend taking at least one capsule for each 800 mg of SAMe that you take. To promote healthy homocysteine metabolism, take 2 capsules once or twice daily. Betaine is very safe to take, and some individuals may benefit from even higher intakes, as recommended by a nutritionally informed practitioner.
Can vegetarians take this product?
Yes, it is suitable for vegetarians and vegans.
Is this product the same as Betaine HCl?
No. That is a different dietary supplement, a digestive aid. This product, Betaine TMG, is not a digestive aid and is directed primarily at promoting brain health.

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