ProBrainBiotics 60ct

Support Your Gut – Brain Connection! Announcing ProBrainBiotics – the supplement that supports your brain while supporting your gut.

ProBrainBiotics 60ct

Clinical research found that probiotics that support healthy gut function can also support healthy brain function.

Did you know that your intestines hold trillions of bacterial cells that contribute to your health on an everyday basis? Our gastrointestinal (GI) tract or “gut” houses a diverse population of “friendly” bacteria (technically “the gut microbiome”) that are symbiotic with us—they support our health and wellbeing as we give them food and shelter. The two probiotics in ProBrainBiotics have been put through two double-blind, placebo-controlled clinical trials and were found to benefit healthy intestinal function, mood, and coping with occasional anxiety possibly related to stressful experiences.

To properly appreciate probiotics, it is crucial to understand that each probiotic species will typically have various strains (think of them as subspecies), each of which is meaningfully different from other strains in both genetic character and biological function. The strains used in ProBrainBiotics are the same as those that proved beneficial in the two double-blind clinical trials.1,2

First Clinical Trial with Pro-Brain Probiotics
In a 2008 double-blind, placebo-controlled clinical trial with healthy volunteers, gastrointestinal discomforts thought to be related to occasional stress were noticeably improved by a combination of Lactobacillus helveticus Strain R0052 and Bifidobacterium longum Strain R0175 taken daily for three weeks.1 The probiotic combination used in this trial is identical to the ProBrainBiotics formula, and used at the same potency (3 billion CFU or colony forming units).

Second Clinical Trial Finds Brain Benefits
Another double-blind, placebo-controlled clinical trial with this very same combination of probiotic strains, at the very same dosage, was published in 2011. Taken for 30 days, it was found to measurably promote healthy mood and to assist in coping with occasional anxiety likely related to occasional stress.2,3 These improvements were statistically significant when compared to the placebo group. This probiotic combination is unique for its benefits to mood as well as gastrointestinal comfort.

Clinical Trial References
1. Diop L, others. Nutrition Research 28:1 (2008).
2. Messaoudi M, others. British Journal of Nutrition 105:755 (2011); addendum in Messaoudi M, others. Gut Microbes 2:256 (2011).


Quality product

We did a lot of research on probiotics before deciding on ProBrainBiotics. It is high quality and working well for us.

Definite positive effects with regular use.

I have taken ProBrainbiotic for well over a year. Benefits are digestive issues (such as gas/bloating) have subsided. I tolerate dairy better plus I experience/added advantage of clearer thinking/less brain fog (supplemented by Brain & Memory Boost).

Outstanding Product

This is an outstanding product. The information about it is very compelling and thorough.

WHAT? Out of stock? No way!

I have taken PROBRAINBIOTICS for two months and waiting for my next shipment, but they are out of stock! I have a very noticeable difference when not taking PROBRAINBIOTICS.

Terrific Probiotic

Worth the price.

Improved health status and recommend this product!

About 1 1/2 years ago my physician recommended that I take a probiotic. Simultaneously, also through my physician, I became aware of and started the Amen Brain Warrior series. After trying the Amen probiotic, I noticed fewer digestive issues/discomfort. I have continued taking the product and feel the advantages. At the time of my last annual checkup, my physician was extremely pleased with my improvement and recommended just continue what I have been doing. Feeling better and recommend this probiotic!

Less bloated, mood improvement

Decided to fix my gut first so that I could absorb nutrients and vitamins better. Results after 3-4 weeks - I feel less bloated and appear to have lost unnecessary weight. I also notice that my mood has improved.

Feeling better

I started taking this along with Dr. Amen's serotonin supplements and feel a remarkable difference in my mood and my stomach problems. I feel like this is supporting the health of my gut and my brain. Would recommend.

love this product

I have only been on this product for about a month and have seen a difference in my stomach and my moods. It's wonderful my husband has even commented he has noticed I am happier.

Great product

I've been taking this for over a year and love it. Great product!

Love it!

It's been 6 weeks since I've started taking this probiotic and I have seen much improvement. My gut feels stronger and my mind! Highly recommend this product!

Highly satisfied.

About a year ago I was advised by my physician to begin taking a probiotic. I chose this one and have continued using consistently. I recently realized that I haven't had digestive issues for months. Works well for me!

When it comes to your health, no reasonable option should be discounted or discarded.

All the most credible reports that I have read claim that your gut constitutes 70 to 80% of your immune system. I have also read a few articles that claim that your body’s intestinal biome, when in proper balance, is essential to the proper function of all your organ systems.
I have been taking ProBrainBiotics simply because it is targeted to the most import organ system in my body — my brain and nervous system that provides consciousness and the capacity to learn, reason and function properly. I cannot objectively gauge how effective PBB actually is, but every little bit helps! At 71 years old, I need all the help that I can get. If I live as long as my mother and father did, I have at least 20 more years of life, perhaps more because I take better care of myself than they did. I do not want to live forever — I just want to be as healthy as I can possibly be as long as I live.

It's great!

I definitely noticed a difference, very impressive!!! It worked as advertised.

Works well, wish it didn't have traces of dairy/soy

This is a great probiotic, and I'd recommend it. It has dairy and soy in it, so I've had to stop taking it for now, but it helped when I was taking it! I wish it didn't have dairy and soy in it, because I can't have those now due to other (not gut-related) health issues.

Thumbs up!

I've always had an issue with my stomach. I started taking ProBrainBiotic and I slowly started to see a difference. This is week 3 and I don't feel bloated and any discomfort in my stomach. I will continue to take to regulate my stomach. Great product.

Dr. Amen's ProBrainBiotics are great! I highly recommend them for everyone!

I have had issues with my stomach for years so I was skeptical about these probiotics because I've tried several in the past. I've struggled with diarrhea, being bloated and stomach cramps after eating. Since I began taking Dr Amen's probiotics I have finally been able to eat and enjoy my meals well after I've eaten!

Good Probiotic

My doctor encouraged me to take a good quality probiotic so I have been taking ProBrainBiotic for about a month. I have had no adverse side effects. Digestion and elimination are going very well.

Great Probiotic

I have noticed that I do have more energy and I am definitely more "regular". No cramps, no bloating and no upset tummy. I highly recommend this product.

Great product!

I'm really glad I started taking these. No refrigeration needed so easy to take with me when traveling. They also help my digestion and don't give me any issues. Won't be without them.


Since I started taking these Probiotics I can really feel the difference. Really beginning to see what they mean when the experts say, "The gut is the 2nd brain." Can't wait until they develop a Prebiotic supplement as well.

Best probiotic

By far this is the best probiotic I have used. It helps with my GI symptoms and also my mood.


I work for an Integrative Medical Practice and have learned much about the benefits of specific probiotic strains. This one product specifically targets the support of positive mood. This has been a wonderful addition to my supplementation. I feel more "even" throughout the day.



I highly recommend and trust ProBrainBiotics!

I have been studying Dr. Amen's Brain Health Coaching Course. I encourage anyone interested to do so. What I have learned is that brain health equals health. We have had challenges in our family and through taking the course and applying the knowledge that I have learned to the supplements each of us require, we are all in a much better place. We have taken probiotics for years. We are now taking ProBrainBiotics. The reasons for our switch is because I trust Dr. Amen and therefore this product; the link between brain and gut health is enormous and I need to be sure that a probiotic is working for both; and because we have stress in our family and probiotics helps to regulate mood. I have learned that there is never a single magic pill. We are too complex for that. Learning, understanding and knowing about brain and body health is necessary for the health and happiness of each member of my family. I consider this my job and I accept it gladly. Because of the eating habits and diets of the general population, which do not create an environment for healthy gut bacteria to grow and multiply, it is crucial that we take a probiotic. ProBrainBiotics is one of the best that I have found. I highly recommend them.

A Must Have!

I do not want to be without my ProBrainBiotics. Some probiotics were hard to take but this one is easy on my gut and helps with regularity.

No more bloating!

This product has helped me with my gastrointestinal issues. It is now part of my arsenal of, Dr. Amen supplements.

It's working for my son

My son is taking this along with several other formulas and he says it's helping.

Try it with other lifestyle corrections

I have been on this supplement for 2 weeks and I feel great. It is tough to determine how much credit this product gets because I started Brain Body and Power, started a good diet, and started exercising all at the same time. The thing is it is working for me. I feel more positive, more energetic, and more motivated. I recommend my approach. Give it a try. It worked for me, it could work for you.

Positive results with no side effects compared to other similar products.

Positive results with no side effects compared to other similar products.


This is a great probiotic!

Best probiotic I've ever taken!

Been using Dr. Amen's ProBrainBiotics for several months now and have noticed significant positive results. Knowing that my gut is my "second brain" makes me realize the importance of a probiotic and this one is the best!

They make a difference! Great product.

I first started taking the ProBrainBiotics several months back, and noticed an improvement in my digestion. They work great! I ran out a month or so ago and have noticed a difference once I stopped taking them. I am going to order more right now, and am going to set up auto delivery so I don't run out again!

Great Product

I am pleased to have access to this high quality probiotic, at such a great price.

I've been taking these for two months and have seen such an awesome difference in how I feel!

These have been a game changer! Love how I'm feeling!

Positive mindset almost from day 1. I love that !

Beautiful product. Helped me balance my mood within 30 days.

Top notch quality

One of the best probiotics I've ever used! Top notch quality as always.

From someone you can trust to provide exactly what your gut needs. Love these probiotics!

Watching the Brain Warriors Way and realizing that my gut is critical for my brain health. ProBrainBiotics offer me exactly what I need.

There's nothing else out there as good as this supplement.

Awesome supplement, love it.
Thank you, Dr. Amen!

I feel much better since starting these probiotics

As a Brain Warrior I work on cultivating my positive bacteria, which I think is really helping!

Noticeable Difference in Digestion and Mood

Probiotics are the one supplement I never thought to take, prior to the Brain Warrior's Way class. So glad to have discovered them, because the difference is more noticeable with this than with any other single supplement I've tried.

This is helping me!!

I took this ProBrainBiotics for two months and I would re-order this product. Before I took this, I was very moody, very teeny tiny things would tick me off and I had difficult bowel movement. I could have no bowel movement at all in the whole week. My bowel movement got easier in the second month I took this supplement. I was so happy because toxins were passed out of my body. My face looks better and healthier and my mood got better, not so grouchy now.

My body now responds better when under stress

The ProBrainBiotics have been beneficial to my health, especially seen in how my body responds to stress. My gut would go crazy when I was under lots of stress, but now it responds much better than it did before I began taking ProBrainBiotics.

Simple and Effective

My worries seems to have lessened, and not insignificantly, since introducing the probiotic to my daily regimen. I love that the capsules twist open so I can add this to something like a smoothie instead of trying to swallow the pill whole, and that the contents are flavorless. I used to try to get all my good bacteria from food sources, which was rather a struggle. This is much easier, and it works.

I started with Brain & Memory Power Boost and Neurovite in March. I have added the other and I am really starting to feel clearer.

After having cancer in 2003, I had chemo and radiation. I have never completely felt healthy since. My work was suffering because of the brain fog. I have been taking ProBrainBiotics, Brain & Memory Power Boost, Omega Power, Neurovite, and Focus & Energy and am noticing a big difference.

Two Thumbs Up!

Working great and no side effects.


Helping my gut seems to help my mood! I will purchase again.

Excellent supplement

I started taking this recently and have noticed a difference in my digestion. Knowing the brain-gut connection makes a good product like Dr. Amen's worth the effort of adding to my daily routine.

Probiotics are important -- but a Probrainbiotic is a better way to go!

My gastroenterologist told me I had to take a probiotic -- I immediately went to Dr. A's supplements and found this product! I have been using it knowing that Dr. A's supplements are safe and most effective!

Great new product

Recently added this to my regime. Really like how Amen promotes the connections between brain and gut. So far digestion has been good and have maintained good mood and mental clarity.

Probiotics are necessary and these are a winner

I have taken similar products with similar ingredients so don't know if I have noticed a tremendous difference, but I trust Amen supplements more than other places for sourcing best ingredients and will continue to buy through here.

Excellent product

Since I started taking it about a month ago, my digestion has never been better!

Good for digestion

Good product! Helps my digestion

Excellent product that has made me feel so much better than others I was on.

I have been on so many probiotics that just barely keep it all together for me and after 2 weeks I feel like I don't have issues at all. It is affordable and well worth changing whatever you are taking to try this. I am a very happy consumer and have recommended it to my friends.

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Ingredients & Facts

ProBrainBiotics contains the precise probiotic strains at the same potency used in the two clinical trials of gut-brain cooperation.
  • Lactobacillus helveticus Strain R0052
    Helps maintain the healthy intestinal structure, healthy intestinal immune function, and healthy makeup of the gut microbiome.
    • Efficiently implants in the intestine after oral intake
    • Supports the tight “seal” of the gut lining that prevents leakage of intestinal contents into the surrounding tissues.
    • Supports healthy immunity
  • Bifidobacterium longum Strain R0175
    Bifidobacteria are important contributors to intestinal health by helping to digest complex carbohydrates and producing substantial amounts of short chain fatty acids that have a strong positive influence on the cells that line the intestine. The clinical trials indicate this particular strain of bifidobacterium works particularly well with Lactobacillus helveticus R0052 as a dietary supplement for overall intestinal health and for coping with occasional stress.
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving % DV
Lactobacillus helveticus
Strain R0052
2.7 billion CFU1
Bifidobacterium longum
Strain R0175

0.3 billion CFU1
1CFU = Colony-Forming Unit, number of live bacteria

† Daily Value (DV) not established.
Other Ingredients: Hypromellose (vegetarian capsule), potato starch, magnesium stearate.

CONTAINS DAIRY (traces), SOY (traces), Free from gluten, wheat, yeast, eggs, corn, artificial colors or preservatives.

Refrigeration not required. Store in a cool, dry place, away from light. KEEP OUT OF REACH OF CHILDREN.

Dr. Amen talks about ProBrainBiotics

ProBrainBiotics supports healthy intestinal comfort, while also helping support healthy mood and coping with occasional anxiety possibly related to times of stress.

The Science

  • Lactobacillus helveticus (previously called Lactobacillus acidophilus) Strain R0052
    Helps maintain the healthy intestinal structure, healthy intestinal immune function, and healthy makeup of the gut microbiome. Efficiently implants in the intestine after oral intake, supports the tight “seal” of the gut lining that prevents leakage of intestinal contents into the surrounding tissues, and supports healthy immunity.
  • Bifidobacterium longum Strain R0175
    Optimizing gut health is a key nutritional component in supporting brain function. The enteric microbiome consists of trillions of bacteria that outnumber the cells in our body by a ratio of 10:1, and there is increasing evidence in the literature that alterations in its composition can induce neurochemical changes in the brain that significantly impacts our mood and ability to regulate stress. A clinical trial in the general population of healthy adults where participants took a combination of Lactobacillus helveticus and Bifidobacterium longum for a 30 day time frame demonstrate improved mood and a reduction in anxiety and stress.1,2 This suggests that the use of probiotics can serve to support gut microbiome function and a healthy mood.
    1. Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr. Mar 2011;105(5):755-764.
    2. Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut microbes. Jul-Aug 2011;2(4):256-261.

Frequently Asked Questions

How do I take ProBrainBiotics?
Take one or two capsules daily with a meal, or as recommended by a physician.

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