Methylfolate (MF), technically methyltetrahydrofolate, is a form of the folate vitamin that is better utilized than folic acid or other folates. MethylFolate is essential for mood, cognition, behavior, and overall brain and body health.



Methyl Support for Mood, Brain Health and Wellbeing

Promotes Healthy Mood
Methylfolate (MF) is the body's most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood. In clinical trials, MF corrected methyl deficiency while promoting healthy mood and overall brain health.

Highly Bioavailable Source of Methyl Groups
Normally, to be utilized by the body dietary folates from foods or supplements must first be converted to methylfolate, identical to MF. But the enzymes involved in this conversion process often carry mutations that impair their activity, so that more than 1 in 4 people are inefficient at converting folates to MF. High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAME (s-adenosyl-methionine) and other methyl cofactors that manage the body's extensive networks of methyl metabolism.

Promotes Metabolic Recycling of Homocysteine
Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine. If allowed to build up in the blood and other tissues, HCy can become toxic. MF facilitates the recycling of HCy to methionine, thereby curbing its toxic potential.

Supports Brain Health Across the Lifespan
Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and all across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA. Nerve cells especially need methyl to make their synapses (which connect them to other nerve cells) and to make their myelin insulation (which speeds conduction of their electrical signals to other nerve cells). They also need methyl for their dopamine, adrenaline and noradrenaline neurotransmitters that regulate mood, and to make the hormone melatonin that regulates sleep. MF is a key nutrient not just for our brain health, but for our total health and wellbeing as well.


Now part of my daily regimine.

This is the first time trying Methylfolate which I now take with a number of Dr. Amen's supplements including Neurovite, Neurolink, Omega3, Serotonin Mood Support, GABA Support and Vitamin D. There is a definite positive difference - this product enhances the others as if it is a catalyst for them..

Super value & quality

Awesome product - high quality supplement for a grwat orice

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Ingredients & Facts

  • MethylFolate
    Folate is a vitamin that the body has to obtain from foods or supplements. Methylfolate (MF) is the body's most active form of folate and its main resource for methyl groups. Unlike food folates and folic acid, MF does not require conversion by the enzyme MTHFR (methylenetetrahydrofolate reductase), which is notorious for carrying crippling mutations such as C677T. Some 200 enzymes use MF to make large quantities of s-adenosylmethionine (SAMe), an essential cofactor for the mood neurotransmitters dopamine, adrenaline and noradrenaline. MF supplies our cells with methyl for crucial survival functions: to make and maintain their DNA and genes, generate phospholipids for their cell membranes, recycle potentially toxic homocysteine, backup antioxidant defenses. The brain's neurons and support cells need MF to construct their billions of synaptic connections and to produce myelin insulation vital for their electrical signaling. They also need methyl to make melatonin, the sleep hormone. Numerous clinical studies document MF's essentiality for fetal brain, heart and other healthy organ development; for healthy mood, cognition and behavior; and for overall wellbeing from birth through old age. Folate can be depleted by drugs such as antacids, antibiotics, aspirin and other painkillers, certain diuretics, estrogen replacement therapy, anticonvulsants, and SSRI psychotherapeutics. Supplementing with MethylFolate from BrainMD Health helps ensure that the brain and body will receive sufficient methyl to maintain health and wellbeing. It is fully compatible with SAMe Mood & Movement 400 and with Betaine TMG, and may well enhance their mood benefits.
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV
Folate (as Quatrefolic methylfolate,
5-methyltetrahydrofolate, glucosamine salt)
5 mg 1,250%
* Daily Value (DV) not established.
Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, silicon dioxide, magnesium stearate.

Free from sugar, dairy, gluten, wheat, yeast, soy, eggs, corn, and artificial colors or flavorings.

Frequently Asked Questions

How do I know whether I need this supplement?
Methylfolate is a great supplement to support mood, especially in conjunction with SAMe and Betaine TMG. It also supports memory and the other higher brain functions. Since MF is essential for fetal development, women of reproductive age would be prudent to monitor their folate status and consider taking this supplement. Alcohol, smoking, and oral contraceptives all can deplete the body's folate. Inherited mutations in folate-processing enzymes affect up to 1 in 2 individuals of some ethnic groups. Taking MethylFolate ensures these individuals will receive folate they can utilize. This supplement is also a superior folate source for those without such mutations precisely because it is so efficiently utilized.
This supplement is very potent. Is it safe?
Methylfolate's safety is well documented, and this (and higher potencies) have been used safely and with great success for many years. MethylFolate is indicated for correcting confirmed folate deficiency, for promoting healthy mood, and for any other situations where folate supplementation is recommended.
What's the best way to take this supplement?
The basic dose is 1 capsule daily, taken with food. This supplies 5000 micrograms (5 mg) of methylfolate. We recommend that when under a physician's supervision, up to 3 caps (15 mg) can be taken daily.
I'm currently taking methotrexate - will this supplement be a problem?
We advise anyone taking methotrexate to consult a nutritionally-informed physician before using this product.
Can vegetarians take this product?
Yes, it is suitable for vegetarians and vegans.
What is the functional relationship of this product with SAMe?
Our liver cells need methylfolate to make SAMe. MethylFolate generously facilitates this process. The body uses a lot of SAMe, so boosting internal SAMe production may improve the benefits of SAMe supplementation, whether for mood, joint health or liver health.
How does this product work with Betaine TMG (Trimethylglycine)?
BrainMD's product Betaine TMG is a neat backup methyl source. It works to bypass the methyl enzyme mutations, promote HCy recycling and generally support methyl metabolism. MethylFolate and Betaine TMG complement each other's beneficial actions, and both complement SAMe Mood & Movement 400.
Is this product compatible with other dietary supplements?
Yes, it is absolutely compatible with multiple vitamin/mineral supplements, fish oils, herbals, and other responsibly-formulated dietary supplements. Further, MethylFolate's multiple methyl actions tend to reinforce the benefits of other dietary supplements.

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